Clinical Trials & COVID-19

Health Care Professionals

NOTE: Information on this webpage is applicable to Healthcare Professionals (HCPs) only.

The CT-0508 Study 101 and CT-0508 in combination with pembrolizumab substudy are sponsored by Carisma Therapeutics. It is a Phase 1, first in human clinical research study to explore the safety and tolerability of adenovirally transduced autologous macrophages engineered to contain an anti-HER2 chimeric antigen receptor in subjects with HER2 overexpression  in  solid tumors. This study is currently taking place in the USA with 7 study centers currently located  in California, North Carolina, Oregon, Pennsylvania, Tennessee, Texas, and Washington.

Primary study objective

Main Study

Assess the safety and tolerability of CT-0508 by estimating the frequency and severity of adverse events in subjects with HER2 overexpression in solid tumors. [Time Frame: 14 months]

CT-0508 in Combination with Pembrolizumab Substudy

Assess the safety and tolerability of CT-0508 in combination with pembrolizumab in subjects with HER2 overexpressing solid tumors. [Time Frame: 14 months]

Study Treatment & Rationale

CT-0508 is a cell product comprised of autologous, peripheral blood monocyte-derived, pro inflammatory macrophages, transduced with an adenoviral vector containing an anti-HER2 CAR.

Adoptive T cell–based cellular therapies have led to remarkable advances among patients with hematologic malignancies, but not in those with solid tumors. Among the multiple factors impeding T cell immunotherapy in solid tumors is the inability of T cells, including CAR-T cells, to infiltrate the microenvironment surrounding tumor cells. Macrophages, by contrast, are actively recruited into the tumor microenvironment. While macrophages contain the necessary machinery for phagocytosis and antigen presentation, macrophages in the tumor microenvironment (TME), called tumor-associated macrophages (TAMs), typically demonstrate immunosuppressive rather than antitumor behavior. Thus, macrophages engineered to be proinflammatory may be an ideal vector to administer adoptive cellular therapy in solid tumors.

Please fill out the following form:

*Do not fill out if you are a patient interested in joining the study. Visit the to email the site closest to you.

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If you are interested in referring a patient, you can navigate to the "Refer a patient" section at the bottom the page and use the interactive map to locate and contact a nearby study site.
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Study Overview

Participation in the CT-0508 main study could last about 13 months from the screening visit and is separated into 2 groups. Study design includes the following:

Pre-infusion Period

Both Groups (7 weeks)

Infusion Period

Group 1 (Day 1, 3, & 5)

Group 2 (Day 1)

Post-infusion Period

Group 1 (Day 8 through Week 4)

Group 2 (Day 2 through Week 4)

Efficacy Follow-up and End of Study Visit

Both Groups (Weeks 8 through 52)

CT-0508 in Combination with Pembrolizumab substudy

Key eligibility criteria

Inclusion Criteria:

Exclusion Criteria:

*Other protocol-defined Inclusion/Exclusion criteria may apply.

Contact and additional information for the CT-0508 study:

For more information, please contact Carisma Therapeutics via email at .

Send Email

Additional study information can also be found on

Refer a patient

Use the filters, map, and listing to find the nearest study clinic. You can contact the study clinic using the associated email link or phone number.

City of Hope

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1500 E. Duarte Road, Duarte, CA 91010
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Fred Hutchinson Cancer Research Center - HCP

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825 Eastlake Avenue East Seattle, WA 98109
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MD Anderson Cancer Center

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1155 Pressler St, Unit 1354, Houston, TX 77230
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North Carolina Comprehensive Cancer Care Center

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450 West Dr, Chapel Hill, NC 27599
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North Carolina
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Oregon Health & Science University (OHSU)

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3485 S Bond Ave, Building 2 Portland, OR 97239
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Sarah Cannon and HCA Research Institute

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250 25th Ave N., Suite 307, Nashville, TN 37203
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University of Pennsylvania Abramson Cancer Center

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3400 Civic Center Boulevard, Philadelphia, PA 19104
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